Metabolism Miracle Research Review
A compilation of research demonstrating the effectiveness of each ingredient in Metabolism Miracle.
Metabolism Miracle contains:
• Vitamin B-12 (cyanocobalamin)
• Iodine (as K Iodide)
• Magnesium (oxide)
• Zinc (as Zn Picolinate)
• Selenium (as L-Selenomethionine)
• Copper (as Cu Picolinate)
• Manganese (amino acid chelate)
• Molybdenum (amino acid chelate)
• L-Tyrosine
• Schizandra (herb powder)
• Ashwagandha Root (herb power)
• Bladderwrack (herb powder)
• Cayenne pepper (herb powder)
• Kelp
Vitamin B-12 (cyanocobalamin)
Rhode, B., Arseneau, P., Cooper, B., Katz, M., Gilfix, B. and MacLean, L. (1996). Vitamin B-12 deficiency after gastric surgery for obesity. The American Journal of Clinical Nutrition, 63(1), pp. 103-109.
Key Takeaway:
B-12 supplementation may be valuable while obesity treatment.
Pancharuniti, N., Lewis, C., Sauberlich, H., Perkins, L., Go, R., Alvarez, J., Macaluso, M., Acton, R., Copeland, R., and Cousins A. (1994). Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease. The American Journal of Clinical Nutrition, 59(4), pp. 640-948.
Key Takeaway:
B-12 supplementation can help in coronary artery disease prevention.
Morris, M., Jacques, P., Rosenberg, I. and Selhub, J. (2007). Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. The American Journal of Clinical Nutrition, 85(1), pp. 193-200.
Key Takeaway:
B-12 supplementation may play a role in anemia and cognitive impairment treatment.
Iodine (as K Iodide)
Neal, A., Petterborg, L. and DiMarco, N. (2013). The association between dietary iodine and body composition in Caucasian females between the ages of 18 and 60. The FASEB Journal, 27(1), Supplement 859.12.
Key Takeaway:
Iodine supplementation may improve lean body mass.
García-Solís, P., Solís-S, J., García-Gaytán, A., Reyes-Mendoza, V., Robles-Osorio, L., Villarreal-Ríos, E., Leal-García, L. and Hernández-Montiel, H. (2013). Iodine nutrition in elementary state schools of Queretaro, Mexico: correlations between urinary iodine concentration with global nutrition status and social gap index. Arquivos Brasileiros de Endocrinologia & Metabologia, 57(6), pp. 473-482.
Key Takeaway:
Iodine supplementation may regulate body mass index.
Magnesium (oxide)
YAKINCI, G., PAÇ, A., KüÇüKBAY, F., TAYFUN, M. and GüL, A. (1997). Serum zinc, copper, and magnesium levels in obese children. Pediatrics International, 39(3), pp. 339-341.
Key Takeaway:
Magnesium supplementation may be related with obesity.
Nielsen, F. (2010). Magnesium, inflammation, and obesity in chronic disease. Nutrition Reviews, 68(6), pp. 333-340.
Key Takeaway:
Magnesium supplementation can help to prevent obesity.
Guerrero-Romero, F. and Rodríguez-Morán, M. (2002). Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects. International Journal of Obesity, 26(4), pp. 469-474.
Key Takeaway:
Magnesium supplementation can prevent the obesity.
Zinc (as Zn Picolinate)
Di Martino, G., Matera, M., De Martino, B., Vacca, C., Di Martino, S., Rossi, F. (1993). Relationship between zinc and obesity. Journal of Medicine, 24(2-3), pp. 177-183.
Key Takeaway:
Zinc supplementation can affect obesity conditions.
Chen, M., Lin, P., Lin, W. and Cheng, V. Zinc in hair and serum of obese individuals in Taiwan. The American Journal of Clinical Nutrition, 48(5), pp. 1307-1309.
Key Takeaway:
Zinc supplementation can be related with a normal body weight.
Tungtrongchitr, R., Pongpaew, P., Phonrat, B., Tungtrongchitr, A., Viroonudomphol, D., Vudhivai, N., Schelp, F. (2003). Serum copper, zinc, ceruloplasmin and superoxide dismutase in Thai overweight and obese. Journal of the Medical Association of Thailand, 86(6), pp. 543-551.
Key Takeaway:
Zinc supplementation can affect the obesity-related metabolism.
Selenium (as L-Selenomethionine) 
Zikić, R., Stajn, A., Ognjanović, B., Saicić, Z., Kostić, M., Pavlović, S., Petrović, V. (1998). The effect of cadmium and selenium on the antioxidant enzyme activities in rat heart. Journal of Environmental Pathology, Toxicology and Oncology, 17(3-4), pp. 259-264.
Key Takeaway:
Selenium supplementation can eliminate a toxic metal activity.
BROOKS, J., METTER, E., CHAN, D., SOKOLL, L., LANDIS, P., NELSON, W., MULLER, D., ANDRES, R. and CARTER, H. (2001). PLASMA SELENIUM LEVEL BEFORE DIAGNOSIS AND THE RISK OF PROSTATE CANCER DEVELOPMENT. The Journal of Urology, 166(6), pp.2034-2038.
Key Takeaway:
Selenium supplementation can prevent a cancer development.
Levander, O. and Morris, V. (1984). Dietary selenium levels needed to maintain balance in North American adults consuming self-selected diets. The American Journal of Clinical Nutrition, 39(5), pp. 809-815.
Key Takeaway:
Selenium supplementation may help to achieve lean body mass.
Nawrot, T., Staessen, J., Roels, H., Den Hond, E., Thijs, L., Fagard, R., Dominiczak, A. and Struijker-Boudier, H. (2006). Blood pressure and blood selenium: a cross-sectional and longitudinal population study. European Heart Journal, 28(5), pp.628-633.
Key Takeaway:
Selenium supplementation can decrease risk of the high blood pressure.
Olivieri, O., Girelli, D., Azzini, M., Stanzial, A., Russo, C., Ferroni, M. and Corrocher, R. (1995). Low Selenium Status in the Elderly Influences Thyroid Hormones. Clinical Science, 89(6), pp.637-642.
Key Takeaway:
Selenium supplementation alters thyroid hormones levels.
Copper (as Cu Picolinate)
Wang, C., Chang, W., Zeng, W., et al. (2011). Concentrations of calcium, copper, iron, magnesium, potassium, sodium and zinc in adult female hair with different body mass indexes in Taiwan. Clinical Chemistry and Laboratory Medicine, 43(4), pp. 389-393.
Key Takeaway:
Copper supplementation can regulate body mass index.
Wang, C., Chang, W., Jeng, L., Liu, P. and Liu, L. (2005). Concentrations of Calcium, Copper, Iron, Magnesium, and Zinc in Young Female Hair with Different Body Mass Indexes in Taiwan. Journal of Health Science, 51(1), pp.70-74.
Key Takeaway:
Copper supplementation may regulate a body mass.
Manganese (amino acid chelate)
Kennedy, M., Failla, M., Smith, J. Jr. (1986). Influence of genetic obesity on tissue concentrations of zinc, copper, manganese and iron in mice. The Journal of Nutrition, 116(8), pp. 1432-1441.
Key Takeaway:
Manganese supplementation may affect the obesity development.
Kazi, T., Afridi, H., Kazi, N., Jamali, M., Arain, M., Jalbani, N. and Kandhro, G. (2008). Copper, Chromium, Manganese, Iron, Nickel, and Zinc Levels in Biological Samples of Diabetes Mellitus Patients. Biological Trace Element Research, 122(1), pp. 1-18.
Key Takeaway:
Manganese supplementation may play a role in the diabetes treatment.
Choi, M. and Bae, Y. (2013). Relationship between Dietary Magnesium, Manganese, and Copper and Metabolic Syndrome Risk in Korean Adults: The Korea National Health and Nutrition Examination Survey (2007–2008). Biological Trace Element Research, 156(1-3), pp. 56-66.
Key Takeaway:
Manganese supplementation may improve blood pressure.
Molybdenum (amino acid chelate
Thompson, K., Chiles, J., Yuen, V., Tse, J., McNeill, J. and Orvig, C. (2004). Comparison of anti-hyperglycemic effect amongst vanadium, molybdenum and other metal maltol complexes. Journal of Inorganic Biochemistry, 98(5), pp. 683-690.
Key Takeaway:
Molybdenum supplementation may provide hypoglycemic activity.
L-Tyrosine
Hellmuth, C., Kirchberg, F., Lass, N., Harder, U., Peissner, W., Koletzko, B. and Reinehr, T. (2016). Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children. Journal of Diabetes Research, 2016, pp. 1-10.
Key Takeaway:
L-Tyrosine supplementation may affect insulin resistance.
Mahmoud, A. (2016). Peptide tyrosine tyrosine (PYY) as a new strategy for treating obesity. Al-Azhar Assiut Medical Journal, 14(3), p. 101.
Key Takeaway:
L-Tyrosine supplementation may lead to the new obesity-regulation metabolites.
Cho, H. (2013). Protein Tyrosine Phosphatase 1B (PTP1B) and Obesity. Vitamins & Hormones, 91, pp. 405-424.
Key Takeaway:
L-Tyrosine supplementation may affect leptin and insulin signaling pathways.
Schizandra (herb powder)
Jeong, E.; Lee, W.; Kim, K. (2009). Effects of Schizandra chinensis Extract on the Growth of Intestinal Bacteria Related with Obesity. Korean Journal of Food Science and Technology, 41(6), pp. 673-680.
Key Takeaway:
Schizandra supplementation may help to control microbial flora.
Park, H., Cho, J., Kim, M., Koh, P., Cho, K., Kim, C., Lee, K., Chung, B., Kim, G. and Cho, J. (2012). Anti-obesity effect of Schisandra chinensis in 3T3-L1 cells and high fat diet-induced obese rats. Food Chemistry, 134(1), pp. 227-234.
Key Takeaway:
Schizandra supplementation can treat obesity.
Roh, C. and Jung, U. (2012). Screening of Crude Plant Extracts with Anti-Obesity Activity. International Journal of Molecular Sciences, 13(12), pp. 1710-1719.
Key Takeaway:
Schizandra supplementation can play a role in obesity treatmen
Ashwagandha Root (herb powder)
Sandhu, J., Shah, B., Shenoy, S., Chauhan, S., Lavekar, G. and Padhi, M. (2010). Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults. International Journal of Ayurveda Research, 1(3), pp. 144-149.
Key Takeaway:
Ashwagandha supplementation may be useful for generalized weakness and to improve strength.
Ziauddin, M., Phansalkar, N., Patki, P., Diwanay, S. and Patwardhan, B. (1996). Studies on the immunomodulatory effects of Ashwagandha. Journal of Ethnopharmacology, 50(2), pp. 69-76.
Key Takeaway:
Ashwagandha supplementation improves blood parameters.
Raut, A., Rege, N., Shirolkar, S., Pandey, S., Tadvi, F., Solanki, P., Vaidya, R., Vaidya, A. and Kene, K. (2012). Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers. Journal of Ayurveda and Integrative Medicine, 3(3), p.111.
Key Takeaway:
Ashwagandha supplementation improves muscle activity and decreases total body fat.
Bladderwrack (herb powder) 
Vázquez-Freire, M., Lamela, M. and Calleja, J. (1996). Hypolipidaemic Activity of a Polysaccharide Extract fromFucus vesiculosus L. Phytotherapy Research, 10(8), pp.647-650.
Key Takeaway:
Bladderwrack supplementation may provide hypolipaemic activity.
Akondi, B., Korukanti, V. and Ponnam, H. (2013). Evaluation of antiobesity activity of Fucus vesiculosus. Indian Journal of Research in Homoeopathy, 7(3), p. 126.
Key Takeaway:
Bladderwrack supplementation may help in obesity treatment.
Lim, J., Lee, S., Kim, T., Jang, S., Kang, S., Koo, H., Sohn, E., Bak, J., Namkoong, S., Kim, H., Song, I., Kim, N., Sohn, E. and Han, J. (2015). Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells. Marine Drugs, 13(2), pp. 1051-1067.
Key Takeaway:
Bladderwrack supplementation may help to prevent a liver damage.
Cayenne pepper (herb powder)
Ahuja, K., Robertson I., Geraghty, D., Ball, M. (2006). Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. The American Journal of Clinical Nutrition, 84(1), pp. 63-69.
Key Takeaway:
Cayenne pepper supplementation may increase fat oxidation.
Kasbia, G. (2005). Functional foods and nutraceuticals in the management of obesity. Nutrition & Food Science, 35(5), pp. 344-352.
Key Takeaway:
Cayenne pepper supplementation may help with obesity treatment.
Astrup, A., Kristensen, M., Gregersen, N., Belza, A., Lorenzen, J., Due, A. and Larsen, T. (2010). Can bioactive foods affect obesity? Annals of the New York Academy of Sciences, 1190(1), pp. 25-41.
Key Takeaway:
Cayenne pepper supplementation may provide a beneficial effect on energy balance.
Kelp
Key, T., Thorogood, M., Keenan, J. and Long, A. (1992). Raised thyroid stimulating hormone associated with kelp intake in British vegan men. Journal of Human Nutrition and Dietetics, 5(5), pp. 323-326.
Key Takeaway:
Kelp supplementation may improve iodine status.
You, J., Sung, M. and Chang, K. (2009). Evaluation of 8-week body weight control program including sea tangle (Laminaria japonica) supplementation in Korean female college students. Nutrition Research and Practice, 3(4), p. 307.
Key Takeaway:
Kelp supplementation can improve subcomponents of quality of life.
Jang, W. and Choung, S. (2013). Antiobesity Effects of the Ethanol Extract of Laminaria japonica Areshoung in High-Fat-Diet-Induced Obese Rat. Evidence-Based Complementary and Alternative Medicine, 2013, pp. 1-17.
Key Takeaway:
Kelp supplementation has a protective effect against a high fat diet induced obesity.
Addition
Clark, С., Bassett, B. and Burge, M. (2003). Effects of kelp supplementation on thyroid function in euthyroid subjects. Endocrine Practice, 9(5), pp. 363-369.
Key Takeaway:
Kelp supplementation may increase both basal and poststimulation thyrotropin.
GARDNER, D., CENTOR, R. and UTIGER, R. (1988). EFFECTS OF LOW DOSE ORAL IODIDE SUPPLEMENTATION ON THYROID FUNCTION IN NORMAL MEN. Clinical Endocrinology, 28(3), pp. 283-288.
Key Takeaway:
Iodide supplementation has a significant inhibitory effect on thyroid hormone secretion.
Takeuchi, T., Kamasaki, H., Hotsubo, T. and Tsutsumi, H. (2011). Treatment of Hypothyroidism due to Iodine Deficiency Using Daily Powdered Kelp in Patients Receiving Long-term Total Enteral Nutrition. Clinical Pediatric Endocrinology, 20(3), pp. 51-55.
Key Takeaway:
Kelp supplementation can be effective to treat hypothyroidism.
Jain, R. and Choi, Y. (2015). Interacting effects of selected trace and toxic metals on thyroid function. International Journal of Environmental Health Research, 26(1), pp. 75-91.
Key Takeaway:
Copper supplementation may increase levels of free and total thyroxines.
Cayir, A., Doneray, H., Kurt, N., Orbak, Z., Kaya, A., Turan, M. and Yildirim, A. (2014). Thyroid Functions and Trace Elements in Pediatric Patients with Exogenous Obesity. Biological Trace Element Research, 157(2), pp. 95-100.
Key Takeaway:
Copper supplementation may correlate with thyroid function.
Agatston, A. (2012). Why America Is Fatter and Sicker Than Ever. Circulation, 126(1), pp. e3-e5.
Key Takeaway:
It is important to educate ourselves and our families on the principles of healthy nutrition and other optimal lifestyle habits.